Assays
Advanced filteringID: 32
Assay type: Transcriptional profiling
Technology type: fluidigm high-throughput taqman platform
Investigation: 1 hidden item
Study: 1 hidden item
Contributor: Maria Thomas
Projects: A3.4: Linking signalling to metabolic functions, Showcase Steatosis
Organisms:
Homo sapiens : [Hepatocyte] (primary cell culture)
SOPs: 2 hidden items
Data files: 5 hidden items
Scales: Not specified
A technology which offers on-chip networks of microfluidc channels.This platform enables us to perform high-throughput real-time PCR with up to 9.216 data points in one run in TaqMan data quality.
Created: 6th Nov 2012 at 06:47 Last updated: 24th Jul 2015 at 12:18
ID: 71
Biological problem addressed: Metabolic network
Investigation: Investigation: Multi-scale model galactose meta...
Study: Study : Galactose metabolism in the liver
Models: 2 hidden items
Contributor: Matthias König
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., C1: The role of blood flow in liver lobule function and morphology, C2: Organization of the sinusoidal system and the liver lobule - referen..., C3: Zonation of metabolism and its regulation
Organisms: Not Specified
SOPs: No SOPs
Data files: No Data files
Scales: Cell, Liver lobule and Liver
We present a multi-scale model of liver galactose metabolism bridging the scales from single-cell metabolism over the tissue level to the whole-organ. The model combines a detailed kinetic model of the cellular galactose metabolism with a tissue-scale perfusion model of the sinusoid. The metabolic capacity of the whole liver is modelled by integrating the heterogeneous contribution of sinusoids differing in blood-flow rates and tissue-architecture. The model was applied to the normal physiological
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Created: 3rd Nov 2013 at 15:17 Last updated: 24th Jul 2015 at 13:30
