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Uploader: Madlen Matz-Soja
Contributor: Madlen Matz-Soja, Rolf Gebhardt, Wolfgang Schmidt-Heck
Other contributors: Not specified
Version: 2
Projects: A1: Cellular metabolism
Scales: Cell
Transgenic mice with a conditional hepatocyte-specific deletion of the Smoothened gene after adolescence were characterized for alterations in gene expression via microarrays.
Created: 20th Oct 2015 at 09:10 Last updated: 3rd May 2017 at 11:12
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Uploader: Andreas Dräger
Contributor: Andreas Dräger
Other contributors: Not specified
Version: 1
Scales: Not specified
The project A3.4 will create a combined model that containes metabolism, gene regulation and signal transduction with main focus on the influence of the nuclear receptors PXR, CAR, and PPARa. To this end, information is gathered from HepatoNet1, TRANSFAC, and Ingenuity aiming at creating an overal model, which will be equipped with kinetic information subsequently. In project B.5 a model of IL6 signal transduction that links of STAT3 and MAPK (ERK) to ADME genes is created using TRANSFAC, Ingenuity,
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Created: 25th Jun 2011 at 11:23 Last updated: 12th Jan 2016 at 08:13
