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Uploader: Data From HepatoSys
Contributor: Andreas Deutsch, Data From HepatoSys, Lutz Brusch, Marino Zerial, Yannis Kalaidzidis
Other contributors: Perla Del Conte-Zerial, Jochen C Rink, Claudio Collinet
Model type: Not specified
Model format: SBML
Scales: Cell
GTPases of the Rab family provide a molecular ID code to the generation, maintenance and transport of intracellular compartments. Here, we addressed the molecular design principles of endocytosis by focusing on the conversion of early endosomes into late endosomes, which entails replacement of Rab5 by Rab7. We demonstrate that intermodule interactions share similarities with the toggle switch described for the cell cycle. However, Rab5-to-Rab7 conversion is rather based on a newly characterized
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Created: 29th Jul 2011 at 17:13 Last updated: 24th Feb 2012 at 14:08
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Download Uploader: Data From HepatoSys
Contributor: Andreas Deutsch, Bianca Habermann, Data From HepatoSys, Lutz Brusch, Marino Zerial, Yannis Kalaidzidis
Other contributors: Perla Del Conte-Zerial, Jochen Rink
Model type: Partial differential equations (PDE)
Model format: SBML
Scales: Cell
This model describes a core process during endocytosis. Intracellular vesicles called early endosomes contain the endocytosed cargo, e.g. signaling components like growth factors and RTKs, pathogens like viruses and nutrients like iron in transferrin. Early endosomes form an interacting pool of thousands of vesicles and jointly constitute the sorting and transport machinery in the endocytic pathway. Together with the cargo, membrane components travel to other compartments of the pathway which
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Created: 1st Aug 2011 at 18:11 Last updated: 24th Feb 2012 at 16:55
