Models
Response of hepatocytes to rapid change in the medium composition (gene regulatory network): Model 1100 freshMedia
Uploader: Data From HepatoSys
Contributor: Data From HepatoSys, Reinhard Guthke, Rolf Gebhardt, Sebastian Zellmer, Wolfgang Schmidt-Heck
Other contributors: Not specified
Model type: Not specified
Model format: SBML
Scales: Cell
Primary hepatocytes were exposed to a stimulus by exchanging culture medium, thereby simulating changes in the blood composition. The expression of genes at different time points was recorded. Differentially expressed genes were clustered using fuzzy c-means algorithm into five groups. The arcs of the possible network were identified using the NetGenerator algorithm under the restriction of biological knowledge. The analysis was restricted to the main metabolic pathways of hepatocytes. The reverse
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Created: 25th Jul 2011 at 14:48 Last updated: 24th Feb 2012 at 15:11