The Process-Interaction-Model: a common representation of rule-based and logical models allows studying signal transduction on different levels of detail
Abstract:
Signaling systems typically involve large, structured molecules each consisting of a large number of subunits called molecule domains. In modeling such systems these domains can be considered as the main players. In order to handle the resulting combinatorial complexity, rule-based modeling has been established as the tool of choice. In contrast to the detailed quantitative rule-based modeling, qualitative modeling approaches like logical modeling rely solely on the network structure and are particularly useful for analyzing structural and functional properties of signaling systems.
Projects: E1: Integration on the cellular level
BMC Bioinformatics
BMC Bioinformatics 13: 251
28th Sep 2012
Katrin Kolczyk, Regina Samaga, Holger Conzelmann, Sebastian Mirschel, Carsten Conradi
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