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Fast and accurate identification of fat droplets in histological images

Authors: André Homeyer, Andrea Schenk, Janine Arlt, Uta Dahmen, Olaf Dirsch, Horst K. Hahn

DOI: 10.1016/j.cmpb.2015.05.009

Date Published: 1st Jun 2015

Projects: D4: Regeneration and Liver Size, Showcase Steatosis

Journal: Computer Methods and Programs in Biomedicine

Citation: Computer Methods and Programs in Biomedicine

Scales: Cell, Liver lobule and Liver

Abstract (Expand)

Background and objective: The accurate identification of fat droplets is a prerequisite for the automatic quantification of steatosis in histological images. A major challenge in this regard is the ...

Created: 25th Jun 2015 at 09:02 Last updated: 29th Jun 2015 at 09:38

Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant

Authors: R. Arlanov, T. Lang, G. Jedlitschky, E. Schaeffeler, T. Ishikawa, M. Schwab, A. T. Nies

PubMed ID: 25896536

Date Published: 22nd Apr 2015

Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development

Journal: Pharmacogenomics J

Citation: Pharmacogenomics J. 2015 Apr 21. doi: 10.1038/tpj.2015.27.

Scales: Not specified

Abstract (Expand)

Multidrug resistance protein 8 (ABCC11) is an efflux transporter for anionic lipophilic compounds, conferring resistance to antiviral and anticancer agents like 5-fluorouracil (5-FU). ABCC11 missense ...

Created: 17th Dec 2015 at 11:41

Fluorescence based cell counting in collagen monolayer cultures of primary hepatocytes

Authors: C Priesnitz, S Sperber, R Garg, M Orsini, F Noor

PubMed ID: 25424145

Date Published: 26th Nov 2014

Projects: A1: Cellular metabolism, C3: Zonation of metabolism and its regulation

Journal: Cytotechnology

Citation: Cytotechnology :

Scales: Cell

Abstract (Expand)

Accurate determination of cell number is essential for the quantitative description of biological processes. The changes should be related to a measurable reference e.g. in the case of cell culture, ...

Created: 14th Jan 2015 at 16:17

Foxf1 SiRNA Delivery to Hepatic Stellate Cells by DBTC Lipoplex Formulations Ameliorates Fibrosis in Livers of Bile Duct Ligated Mice

Authors: Kerstin Abshagen, Malte Brensel, Berit Genz, Kira Roth, Maria Thomas, Volker Fehring, Ute Schaeper, Brigitte Vollmar

PubMed ID: 25619889

Date Published: 11th Aug 2014

Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes

Journal: Curr Gene Ther

Citation: Curr Gene Ther :

Scales: Cell

Abstract (Expand)

Activation of hepatic stellate cells (HSCs) is a key event in pathogenesis of liver fibrosis and represents an orchestral interplay of inhibiting and activating transcription factors like forkhead box ...

Created: 27th Jan 2015 at 10:19

Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells

Authors: Rudolf Arlanov, Andrew Porter, Dennis Strand, Rachel Brough, Darja Karpova, Reinhold Kerb, Leszek Wojnowski, Matthias Schwab, Thomas Lang

PubMed ID: 22290738

Date Published: 28th Feb 2012

Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting

Journal: Hum. Mutat.

Citation: Hum. Mutat. 33(4): 750-62

Scales: Not specified

Abstract (Expand)

The multidrug resistance-associated protein 2 (MRP2/ABCC2) is involved in the efflux of endogenous and xenobiotic substrates, including several anticancer and antiviral drugs. The functional consequences ...

Created: 18th Jul 2012 at 13:34 Last updated: 24th Oct 2013 at 16:16

FASIMU: flexible software for flux-balance computation series in large metabolic networks

Authors: Andreas Hoppe, Sabrina Hoffmann, Andreas Gerasch, Christoph Gille, Hermann-Georg Holzhütter

PubMed ID: 21255455

Date Published: 22nd Oct 2010

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A3.4: Linking signalling to metabolic functions

Journal: BMC Bioinformatics

Citation: BMC Bioinformatics 12: 28

Scales: Not specified

Abstract (Expand)

ABSTRACT: BACKGROUND: Flux-balance analysis based on linear optimization is widely used to compute metabolic fluxes in large metabolic networks and gains increasingly importance in network curation and ...

Created: 7th Feb 2011 at 12:27 Last updated: 24th Oct 2013 at 16:19

Fluxviz - cytoscape plug-in for visualization of flux distributions in networks

Authors: Matthias König, Hermann-Georg Holzhütter

PubMed ID: 22081592

Date Published: 1st Jul 2010

Projects: No Projects

Journal: Genome Inform

Citation: Genome Inform 24(1): 96-103

Scales: Not specified

Abstract (Expand)

Motivation: Methods like FBA and kinetic modeling are widely used to calculate fluxes in metabolic networks. For the analysis and understanding of simulation results and experimentally measured fluxes ...

Created: 4th Jan 2013 at 11:14 Last updated: 24th Oct 2013 at 16:20

Finding one's way in proteomics: a protein species nomenclature

Authors: Hartmut Schlüter, Rolf Apweiler, Hermann-Georg Holzhütter, Peter R Jungblut

PubMed ID: 19740416

Date Published: 9th Sep 2009

Projects: No Projects

Journal: Chem Cent J

Citation: Chem Cent J 3: 11

Scales: Not specified

Abstract (Expand)

Our knowledge of proteins has greatly improved in recent years, driven by new technologies in the fields of molecular biology and proteome research. It has become clear that from a single gene not only ...

Created: 4th Jan 2013 at 12:56 Last updated: 24th Oct 2013 at 16:21

FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity

Authors: Marc Flajolet, Zhongfeng Wang, Marie Futter, Weixing Shen, Nina Nuangchamnong, Jacob Bendor, Iwona Wallach, Angus C Nairn, D James Surmeier, Paul Greengard

PubMed ID: 18953346

Date Published: 26th Oct 2008

Projects: No Projects

Journal: Nat. Neurosci.

Citation: Nat. Neurosci. 11(12): 1402-9

Scales: Not specified

Abstract (Expand)

Abnormalities of striatal function have been implicated in several major neurological and psychiatric disorders, including Parkinson's disease, schizophrenia and depression. Adenosine, via activation ...

Created: 4th Jan 2013 at 11:25 Last updated: 24th Oct 2013 at 16:22