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Quantification of Hepatic Vascular and Parenchymal Regeneration in Mice

Authors: Chichi Xie, Lars Ole Schwen, Weiwei Wei, Andrea Schenk, Sara Zafarnia, Felix Gremse, Uta Dahmen

DOI: 10.1371/journal.pone.0160581

Date Published: 5th Aug 2016

Projects: D4: Regeneration and Liver Size, E3: Horizontal integration on organ scale

Journal: PLoS ONE

Citation: PLoS ONE 11(8) : e0160581

Scales: Liver

Abstract (Expand)

Background. Liver regeneration consists of cellular proliferation leading to parenchymal and vascular growth. This study complements previous studies on cellular proliferation and weight recovery by ...

Created: 26th May 2017 at 09:10 Last updated: 26th May 2017 at 09:12

Quantitative structure-activity relationship models for predicting drug-induced liver injury based on FDA-approved drug labeling annotation and using a large collection of drugs

Authors: Minjun Chen, Huixiao Hong, Hong Fang, Reagan Kelly, Guangxu Zhou, Jürgen Borlak, Weida Tong

PubMed ID: 23997115

Date Published: 31st Aug 2013

Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions

Journal: Toxicol. Sci.

Citation: Toxicol. Sci. 136(1): 242-9

Scales: Liver

Abstract (Expand)

Drug-induced liver injury (DILI) is one of the leading causes of the termination of drug development programs. Consequently, identifying the risk of DILI in humans for drug candidates during the early ...

Created: 19th Jan 2014 at 17:57

Quantitative Evaluation and Prediction of Drug Effects and Toxicological Risk Using Mechanistic Multiscale Models

Authors: Jens Niklas, Juan G Diaz Ochoa, Joachim Bucher, Klaus Mauch

DOI: 10.1002/minf.201200043

Date Published: 14th Nov 2012

Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions

Journal: Mol. Inf.

Citation: Mol. Inf. 32(1) : 14

Scales: Not specified

Abstract (Expand)

Integrating in vitro and in silico approaches has great potential for reducing experimental effort and delivering know-how and intellectual property in drug development. Here, we focus on a possible ...

Created: 16th Jan 2013 at 11:43 Last updated: 24th Oct 2013 at 16:15

Quantitative kinetic analysis of BMP2 uptake into cells and its modulation by BMP-antagonists

Authors: Hamed Alborzinia, Hannah Schmidt-Glenewinkel, Iryna Ilkavets, Katja Breitkopf-Heinlein, Xinlai Cheng, Peter Hortschansky, Steven Dooley, Stefan Wölfl

PubMed ID: 23077176

Date Published: 19th Oct 2012

Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...

Journal: J. Cell. Sci.

Citation: J. Cell. Sci. 126(Pt 1): 117-27

Scales: Not specified

Abstract (Expand)

Bone morphogenetic proteins (BMPs) are members of the TGFβ-family of signaling proteins and play an important role during development and in tissue formation. BMP signaling is a well studied process, ...

Created: 31st Oct 2012 at 09:20 Last updated: 24th Oct 2013 at 16:15

Qualitative translation of relations from BioPAX to SBML qual

Authors: F. Buchel, C. Wrzodek, F. Mittag, A. Drager, J. Eichner, N. Rodriguez, N. L. Novere, A. Zell

DOI: 10.1093/bioinformatics/bts508

Date Published: 24th Aug 2012

Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, Showcase Steatosis

Journal: Bioinformatics

Citation: Bioinformatics 28(20) : 2648

Scales: Cell and Intercellular

Abstract (Expand)

Motivation: The Biological Pathway Exchange Language (BioPAX) and the Systems Biology Markup Language (SBML) belong to the most popular modeling and data exchange languages in systems biology. The focus ...

Created: 25th Aug 2012 at 21:46 Last updated: 24th Oct 2013 at 16:16

Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism

Authors: Matthias König, Sascha Bulik, Hermann-Georg Holzhütter

PubMed ID: 22761565

Date Published: 21st Jun 2012

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A1: Cellular metabolism, A2.5: Integration of insulin and Wnt signalling in hepatocytes, A2: Integration of Signalling Pathways in Hepatocellular Response, A3.4: Linking signalling to metabolic functions

Journal: PLoS Comput. Biol.

Citation: PLoS Comput. Biol. 8(6): e1002577

Scales: Cell and Liver

Abstract (Expand)

Despite the crucial role of the liver in glucose homeostasis, a detailed mathematical model of human hepatic glucose metabolism is lacking so far. Here we present a detailed kinetic model of glycolysis, ...

Created: 12th Jul 2012 at 08:46 Last updated: 24th Oct 2013 at 16:16

qPIPSA: relating enzymatic kinetic parameters and interaction fields

Authors: Razif R Gabdoulline, Matthias Stein, Rebecca C Wade

PubMed ID: 17919319

Date Published: 5th Oct 2007

Projects: HepatoSys

Journal: BMC Bioinformatics

Citation: BMC Bioinformatics 8: 373

Scales: Not specified

Abstract (Expand)

The simulation of metabolic networks in quantitative systems biology requires the assignment of enzymatic kinetic parameters. Experimentally determined values are often not available and therefore ...

Created: 31st Oct 2012 at 14:14 Last updated: 24th Oct 2013 at 16:23

Quantitative analysis of ultrasensitive responses

Authors: Stefan Legewie, Nils Blüthgen, Hanspeter Herzel

PubMed ID: 16098190

Date Published: 16th Aug 2005

Projects: HepatoSys

Journal: FEBS J.

Citation: FEBS J. 272(16): 4071-9

Scales: Not specified

Abstract (Expand)

Ultrasensitive responses are common in cellular information transfer because they allow cells to decode extracellular stimuli in an all-or-none manner. Biochemical responses are usually analyzed by ...

Created: 11th Sep 2012 at 13:13 Last updated: 24th Oct 2013 at 16:24