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Use of Fibonacci numbers in lipidomics - Enumerating various classes of fatty acids

Authors: S. Schuster, M. Fichtner, S. Sasso

PubMed ID: 28071669

Date Published: 11th Jan 2017

Projects: Showcase Steatosis

Journal: Sci Rep

Citation: Sci Rep. 2017 Jan 10;7:39821. doi: 10.1038/srep39821.

Scales: Cell

Abstract (Expand)

In lipid biochemistry, a fundamental question is how the potential number of fatty acids increases with their chain length. Here, we show that it grows according to the famous Fibonacci numbers when ...

Created: 24th Jun 2017 at 17:16

Unraveling liver complexity from molecular to organ level: Challenges and perspectives

Authors: L.A. D'Alessandro, S. Hoehme, A. Henney, D. Drasdo, U. Klingmüller

DOI: 10.1016/j.pbiomolbio.2014.11.005

Date Published: 2015

Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., A2.3: Cross-talk and distinct properties of growth factor signalling reg..., A2.4: Linking signalling pathways regulating liver regeneration and orga..., C5: Structural changes and functional consequences of the liver lobular/..., E1: Integration on the cellular level, Interleukin-6 signalling, Showcase HGF and Regeneration

Journal: Progress in Biophysics and Molecular Biology

Citation: Progress in Biophysics and Molecular Biology 117(1) : 78

Scales: Not specified

Abstract (Expand)

Biological responses are determined by information processing at multiple and highly interconnected scales. Within a tissue the individual cells respond to extracellular stimuli by regulating intracellular ...

Created: 6th Apr 2015 at 12:17 Last updated: 9th Jun 2015 at 10:40

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to the proliferative Ras/RAF and the nutrient-dependent mTOR signaling pathways

Authors: Katarzyna Mleczko-Sanecka, Franziska Roche, Ana Rita da Silva, Debora Call, Flavia D'Alessio, Anan Ragab, Philip E Lapinski, Ramesh Ummanni, Ulrike Korf, Christopher Oakes, Georg Damm, Lorenza A D'Alessandro, Ursula Klingmüeller, Philip D King, Michael Boutros, Matthias W Hentze, Martina U Muckenthaler

PubMed ID: 24385536

Date Published: 5th Jan 2014

Projects: A3.4: Linking signalling to metabolic functions, B1.3: Linking modulation of iron metabolism with the impact of macrophag...

Journal: Blood

Citation: Blood :

Scales: Cell and Intercellular

Abstract (Expand)

The hepatic hormone hepcidin is a key regulator of systemic iron metabolism. Its expression is largely regulated by two signaling pathways, the 'iron-regulated' bone morphogenetic protein ...

Created: 14th Jan 2014 at 12:06

Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification

Authors: Markus Krauss, Rolf Burghaus, Jörg Lippert, Mikko Niemi, Pertti Neuvonen, Andreas Schuppert, Stefan Willmann, Lars Kuepfer, Linus Görlitz

DOI: 10.1186/2193-9616-1-6

Date Published: 2013

Projects: G: Clinical translation

Journal: In Silico Pharmacol

Citation: In Silico Pharmacol 1(1) : 6

Scales: Liver and Organism

Abstract (Expand)

Purpose Inter-individual variability in clinical endpoints and occurrence of potentially severe adverse effects represent an enormous challenge in drug development at all phases of (pre-)clinical ...

Created: 16th Sep 2013 at 13:50 Last updated: 24th Oct 2013 at 16:15

Using Mean Field Theory to Guide Biofunctional Materials Design

Authors: Uwe Freudenberg, Jens-Uwe Sommer, Kandice R. Levental, Petra B. Welzel, Andrea Zieris, Karolina Chwalek, Katja Schneider, Silvana Prokoph, Marina Prewitz, Ron Dockhorn, Carsten Werner

DOI: 10.1002/adfm.201101868

Date Published: 10th Apr 2012

Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., A3.3: Hepatocyte polarity, A3.5: The impact of cell polarity on metabolism detoxification and endoc..., B3: Intercellular communication through cell adhesion

Journal: Adv. Funct. Mater.

Citation: Adv. Funct. Mater. 22(7) : 1391

Scales: Not specified

Abstract (Expand)

Cell-instructive characteristics of extracellular matrices (ECM) resulting from a subtle balance of biomolecular and biophysical signals must be recapitulated in engineered biomaterials to facilitate ...

Created: 29th Nov 2012 at 16:44 Last updated: 24th Oct 2013 at 16:16

Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling

Authors: Michaela Meyer, Sebastian Schneckener, Bernd Ludewig, Lars Kuepfer, Joerg Lippert

PubMed ID: 22293118

Date Published: 31st Jan 2012

Projects: G: Clinical translation

Journal: Drug Metab. Dispos.

Citation: Drug Metab. Dispos. 40(5): 892-901

Scales: Organism

Abstract (Expand)

Active processes involved in drug metabolization and distribution mediated by enzymes, transporters, or binding partners mostly occur simultaneously in various organs. However, a quantitative description ...

Created: 27th Apr 2012 at 10:34 Last updated: 24th Oct 2013 at 16:17

Uncovering metabolic objectives pursued by changes of enzyme levels

Authors: Sabrina Hoffmann, Hermann-Georg Holzhütter

PubMed ID: 19348632

Date Published: 8th Apr 2009

Projects: No Projects

Journal: Ann. N. Y. Acad. Sci.

Citation: Ann. N. Y. Acad. Sci. 1158: 57-70

Scales: Not specified

Abstract (Expand)

Expression profiling and proteomic techniques reveal significant variations in the levels of thousands of mRNAs and proteins in response to environmental changes such as substrate depletion, oxidative ...

Created: 4th Jan 2013 at 12:53 Last updated: 24th Oct 2013 at 16:21

Ultrasensitization: switch-like regulation of cellular signaling by transcriptional induction

Authors: Stefan Legewie, Nils Blüthgen, Reinhold Schäfer, Hanspeter Herzel

PubMed ID: 16261195

Date Published: 28th Oct 2005

Projects: HepatoSys

Journal: PLoS Comput. Biol.

Citation: PLoS Comput. Biol. 1(5): e54

Scales: Not specified

Abstract (Expand)

Cellular signaling networks are subject to transcriptional and proteolytic regulation under both physiological and pathological conditions. For example, the expression of proteins subject to covalent ...

Created: 11th Sep 2012 at 13:11 Last updated: 24th Oct 2013 at 16:24