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Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice

Authors: Chichi Xie, Weiwei Wei, Andrea Schenk, Lars Ole Schwen, Sara Zafarnia, Michael Schwier, Felix Gremse, Isabel Jank, Olaf Dirsch, Uta Dahmen

DOI: 10.3791/53935

Date Published: 2016

Projects: D1: Regulation of Blood Flow and Perfusion in the Liver, D4: Regeneration and Liver Size, E3: Horizontal integration on organ scale, E4: Vertical integration across biological scales

Journal: JoVE

Citation: JoVE (115)

Scales: Liver

Abstract (Expand)

A modified silicone injection procedure was used for visualization of the hepatic vascular tree. This procedure consisted of in-vivo injection of the silicone compound, via a 26 G catheter, into the ...

Created: 14th Sep 2016 at 10:17 Last updated: 14th Sep 2016 at 10:20

Virtual pathway explorer (viPEr) and pathway enrichment analysis tool (PEANuT): creating and analyzing focus networks to identify cross-talk between molecules and pathways

Authors: M. Garmhausen, F. Hofmann, V. Senderov, M. Thomas, B. A. Kandel, B. H. Habermann

PubMed ID: 26467653

Date Published: 14th Oct 2015

Projects: A1.3: Identification of crucial metabolic processes during hepatocyte pr..., A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., A3.5: The impact of cell polarity on metabolism detoxification and endoc..., C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob...

Journal: BMC Genomics

Citation: BMC Genomics. 2015 Oct 14;16(1):790. doi: 10.1186/s12864-015-2017-z.

Scales: Not specified

Abstract (Expand)

BACKGROUND: Interpreting large-scale studies from microarrays or next-generation sequencing for further experimental testing remains one of the major challenges in quantitative biology. Combining ...

Created: 18th Dec 2015 at 12:55

Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors

Authors: A. Emami Riedmaier, O. Burk, B. A. van Eijck, E. Schaeffeler, K. Klein, S. Fehr, S. Biskup, S. Muller, S. Winter, U. M. Zanger, M. Schwab, A. T. Nies

PubMed ID: 26239079

Date Published: 5th Aug 2015

Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development

Journal: Pharmacogenomics J

Citation: Pharmacogenomics J. 2015 Aug 4. doi: 10.1038/tpj.2015.55.

Scales: Not specified

Abstract (Expand)

Human organic anion transporter 7 (OAT7, SLC22A9) is a hepatic transport protein poorly characterized so far. We therefore sought to identify novel OAT7 substrates and factors contributing to variable ...

Created: 17th Dec 2015 at 11:49