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Zonated Quantification of Steatosis in an Entire Mouse Liver

Authors: Lars Ole Schwen, André Homeyer, Michael Schwier, Uta Dahmen, Olaf Dirsch, Arne Schenk, Lars Kuepfer, Tobias Preusser, Andrea Schenk

DOI: 10.1016/j.compbiomed.2016.04.004

Date Published: 1st Apr 2016

Projects: C1: The role of blood flow in liver lobule function and morphology, D1: Regulation of Blood Flow and Perfusion in the Liver, E3: Horizontal integration on organ scale, E4: Vertical integration across biological scales, Showcase Steatosis

Journal: Computers in Biology and Medicine

Citation: Computers in Biology and Medicine

Scales: Cell, Liver lobule, Liver and Organism

Abstract (Expand)

Many physiological processes and pathological conditions in livers are spatially heterogeneous, forming patterns at the lobular length scale or varying across the organ. Steatosis, a common liver disease ...

Created: 13th Apr 2016 at 15:13 Last updated: 13th Apr 2016 at 15:16

Zonation of hepatic fatty acid metabolism - The diversity of its regulation and the benefit of modeling

Authors: J Schleicher, C Tokarski, E Marbach, M Matz-Soja, S Zellmer, R Gebhardt, S Schuster

PubMed ID: 25677822

Date Published: 14th Feb 2015

Projects: C3: Zonation of metabolism and its regulation

Journal: Biochim. Biophys. Acta

Citation: Biochim. Biophys. Acta :

Scales: Intercellular and Liver lobule

Abstract (Expand)

A pronounced heterogeneity between hepatocytes in subcellular structure and enzyme activities was discovered more than 50years ago and initiated the idea of metabolic zonation. In the last decades ...

Created: 26th Feb 2015 at 09:40

Zonation of nitrogen and glucose metabolism gene expression upon acute liver damage in mouse

Authors: Shahrouz Ghafoory, Katja Breitkopf-Heinlein, Qi Li, Catharina Scholl, Steven Dooley, Stefan Wölfl

PubMed ID: 24147127

Date Published: 17th Oct 2013

Projects: C5: Structural changes and functional consequences of the liver lobular/..., Showcase HGF and Regeneration

Journal: PLoS ONE

Citation: PLoS ONE 8(10): e78262

Scales: Not specified

Abstract (Expand)

Zonation of metabolic activities within specific structures and cell types is a phenomenon of liver organization and ensures complementarity of variant liver functions like protein production, glucose ...

Created: 5th Feb 2014 at 12:26