Virtual Liver SEEK

3 items tagged with 'ODE model'.

Models (1)

A description of a detailed ordinary differential equation (ODE) model of Wnt/β-catenin signalling

Uploader: Iryna Ilkavets

Contributor: Andreas Hecht

Other contributors: Not specified

Model type: Ordinary differential equations (ODE)

Model format: PDF (Model description)

Version: 1

Projects: A2.5: Integration of insulin and Wnt signalling in hepatocytes, B2.2: Importance of Wnt- and Hedgehog factors for hepatic stellate cells...

Organism: Not specified

Environment: Not specified

Scales: Cell

It is a link to a supplementary information from a publication: Benary, U., Kofahl, B., Hecht, A. and Wolf, J. (2015), Mathematical modelling suggests a differential impact of β-transducin repeat-containing protein paralogues on Wnt/β-catenin signalling dynamics. FEBS Journal, 282: 1080–1096. doi: 10.1111/febs.13204

http://onlinelibrary.wiley.com/doi/10.1111/febs.13204/suppinfo

The Wnt/β-catenin signalling pathway is involved in the regulation of a multitude of cellular processes by controlling
...

Created: 15th Jun 2015 at 13:22 Last updated: 15th Jun 2015 at 14:19

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Publications (2)

Interleukin-1β Enhances FasL-Induced Caspase-3/-7 Activity without Increasing Apoptosis in Primary Mouse Hepatocytes

Authors: Anna Lutz, Julia Sanwald, Maria Thomas, Ronny Feuer, Oliver Sawodny, Michael Ederer, Christoph Borner, Matjaz Humar, Irmgard Merfort

DOI: 10.1371/journal.pone.0115603

Date Published: 31st Dec 2014

Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato...

Journal: PLoS ONE

Citation: PLoS ONE 9(12) : e115603

Scales: Cell

Abstract (Expand)

Sustained inflammation may increase the susceptibility of hepatocytes to apoptotic cell death and therefore exacerbate liver damage. Here we report that the pro-inflammatory cytokine IL-1β sensitizes ...

Created: 23rd Jan 2015 at 09:58 Last updated: 23rd Jan 2015 at 10:00

A theoretical study of lipid accumulation in the liver-implications for nonalcoholic fatty liver disease

Authors: J Schleicher, R Guthke, U Dahmen, O Dirsch, H G Holzhuetter, S Schuster

PubMed ID: 23999488

Date Published: 4th Sep 2013

Projects: A3.6: Transcription factor network and links to metabolism in NAFLD

Journal: Biochim. Biophys. Acta

Citation: Biochim. Biophys. Acta 1841(1): 62-69

Scales: Cell

Abstract (Expand)

A hallmark of the nonalcoholic fatty liver disease is the accumulation of lipids. We developed a mathematical model of the hepatic lipid dynamics to simulate the fate of fatty acids in hepatocytes. Our ...

Created: 23rd Oct 2013 at 14:55 Last updated: 24th Oct 2013 at 16:14